tic10

TIC10 (ONC-201) inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1 2.

TIC10 Isomer (ONC201 isomer) is an isomer of TIC10, which inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1 2.

TIC10g is a dual inhibitor of Toll-like receptors 7 and 9 (TLR7 and TLR9), effectively suppressing the release of TNF-α mediated by TLR7 and TLR9 in mouse macrophages (with IC50 values of 14.5 μM and 6.5 μM, respectively) and in human B lymphocytes (with IC50 values of 7.69 μM and 11.5 μM, respectively). TIC10g inhibits the activation of NF-κB and MAPK, exhibiting anti-inflammatory activity useful in treating conditions such as systemic lupus erythematosus and rheumatoid arthritis.