tetanus toxin

Tetanus toxin (830-843) from tetanus toxoid is a universal human tetanus toxin T cell epitope. It induces T-cell activation and is used as a helper peptide in vaccinations.

Tetanus Toxin (830–844), a biologically active peptide and a tetanus toxin-derived peptide TT830–844 CD4+ T-cell epitope, exhibits promiscuity by binding to a wide spectrum of HLA–DRB molecules. Consequently, it is anticipated to elicit CD4+ T-cell responses across a broad segment of the human population.

Tetanus toxin 830-843 acetate (Tetanus toxin 830-843 acetate (119260-99-0 free base)) from tetanus toxoid is a universal human tetanus toxin T cell epitope. It induces T-cell activation and is used as a helper peptide in vaccinations.

Tetanus toxin peptide, a specific peptide segment isolated from the toxin produced by Clostridium tetani, serves as an immunogen in mice to induce diabetes. It is also utilized in the research of Type 1 diabetes.

Tetanus Toxin (830–844) TFA is a bioactive peptide. It acts as a CD4+ T cell epitope derived from tetanus toxin (TT830–844). This hybrid CD4+ T cell epitope binds to various HLA-DRB molecules, potentially activating CD4+ T cell responses in a broad population.

Tetanus toxin (830-843) TFA is a potent neurotoxin that reaches the cytoplasm of inhibitory spinal neurons through retrograde axonal transport and endocytosis, preventing these neurons from releasing neurotransmitters.

Tetanus toxin (1,301-1,315) (C. tetani) refers to a peptide fragment located at the C-terminal of the heavy chain of the tetanus toxin derived from C. tetani.

Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 μM, respectively.[1] Ganglioside GT1b-containing liposomes bind to the major coat protein VP1 from Merkel cell polyomavirus (MCPyV), which has been identified in Merkel cell carcinomas, identifying ganglioside GT1b as a putative MCPyV receptor. [2] Ganglioside GT1b decreases production of IL-6, IL-10, IgG, IgM, and IgA in human peripheral blood mononuclear cells (PBMCs) by 31.4, 30.5, 60, 59.5, and 58%, respectively, when used at a concentration of 10 μM [3] . Ganglioside GT1b mixture contains ganglioside GT1b molecular species with C18:1 and C20:1 sphingoid backbones.

Siltartoxatug is a humanized IgG1κ monoclonal antibody specifically targeting tetanus toxin (tetanus toxin), with Human IgG1 kappa, Isotype Control serving as its corresponding isotype control.

Vecantoxatug is a humanized monoclonal antibody designed to target Clostridium tetani toxin (TeNT, a neurotoxin). It specifically binds to the tetanus toxin, preventing the toxin from interacting with cell receptors and thus exhibits antitoxin activity. Vecantoxatug holds potential for tetanus research.

Influenza A NP (383-391) (HLA-B27) is a peptide sequence derived from tetanus toxin. It serves as an epitope for CD4+ T helper cells, exhibiting broad immunogenic properties that enhance the response of CD8+ cytotoxic T lymphocytes (CTL). Additionally, this compound is utilized in the research of breast cancer.