tarpγ

AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels.

LY3130481 is an AMPA receptor antagonist. It is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8 and selectively inhibits AMPA/TARP γ-8 (IC50: 65 nM).

Cefcapene pivoxil hydrochloride hydrate is the pivalate ester prodrug form of cefcapene, a semi-synthetic third-generation cephalosporin with antibacterial activity. After oral administration of cefcapene pivoxil, the ester bond is cleaved, releasing active cefcapene.

Tarperprumig is a monoclonal antibody targeting ALB/CFP, constructed from two linked variable regions of heavy chains.

O-GlyCORTAR protease, recombinantly expressed from E.coli and tagged with His, is an enzyme that relies on O-glycans to cleave proteins carrying mucin-type O-glycans, including sialylated substrates and glycosylated Serine and Threonine residues at the N-terminus. This protease can process various O-glycan structures, such as sialylated core 1 and core 2 configurations, as well as the Tn antigen. Notably, O-GlyCORTAR protease does not cleave terminally modified serine or threonine residues, nor does it act on N-glycosylation sites of glycoproteins.

AMPA receptor modulator-2 (Example 134) is an AMPA receptor modulator with a pIC50 of 10.1 for TARPγ2 dependent AMPA receptor[1]. pIC50 = -lgIC50. [1]. BERRY CYNTHIA G B (US), et al. AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS. Patent. WO2016176460.