stereoselectivity

α-Angelica lactone has cardiotonic activity, may exert their effects by providing an increased contraction-dependent calcium pool to be released upon systolic depolarization.

MY-1B is a covalent inhibitor and an inhibitor of RNA methyltransferase NSUN2 (IC50 = 1.3 μM), featuring stereoselectivity, covalent binding to C271 of NSUN2, and the ability to target PSME1, disrupt proteasome regulatory complexes, and downregulate presentation of specific MHC-I subtypes.

(R,R)-(+)-Hydrobenzoin is an o-diol compound with chiral configuration, which belongs to endogenous metabolites and is often used as chiral ligand or chiral auxiliary reagent in asymmetric synthesis to induce stereoselectivity. (R,R)-(+)-Hydrobenzoin rigid diphenyl glycol skeleton can form complexes with metal ions, which has important application value in catalysis and chiral recognition research.

5R(6S)-EET is a metabolite of Arachidonic acid. It activates the synthesis of endogenous prostaglandin (PGE2), which inhibits Na+ absorption, increases intracellular Ca2+, and promotes transmembrane voltage depolarization. 5R(6S)-EET demonstrates stereoselectivity and is less active compared to 5S(6R)-EET.

Ethyl pivaloylacetate is a significant β-ketoester. It is widely employed as a model substrate in biocatalysis to evaluate the catalytic activity and stereoselectivity of ketoreductase (KRED) tool-boxes. Due to the presence of the bulky pivaloyl (tert-butyl) group, it serves as an excellent probe for assessing the substrate pocket size and enantioselectivity of recombinant enzymes. The enzymatic reduction of this compound yields enantiopure β-hydroxyesters, which are essential chiral building blocks for the synthesis of sophisticated pharmaceutical intermediates.