spns2

SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM.

Spns2-IN-3 (compound 510) is an SPNS2 inhibitor with an IC50 value of 1.2 μM for hSPNS2. It is applicable in research on autoimmune diseases such as multiple sclerosis (MS) and inflammatory bowel disease (IBD), as well as fibrosis, muscle atrophy, metastasis, acute lung injury, rheumatoid arthritis, colitis, Alzheimer's disease, and other conditions linked to SPNS2 activity.

Spns2-IN-1 is a potent Spns2 inhibitor, effectively impeding Spns2-dependent S1P transport with an IC50 value of 1.4±0.3 μM, crucial for modulating the immune response [1].

Spns2-IN-2 (compound 3a) is an inhibitor of SPNS2.

SLF1081851 (TFA) is a Spns2 inhibitor with an IC50 value of 1.93 μM for inhibiting S1P release, playing a key role in development and the immune system.

SLB1122168 is a potent inhibitor of Spns2-mediated sphingosine-1-phosphate (S1P) release, exhibiting an IC50 value of 94 nM [1].

SLB1122168, an inhibitor targeting the sphingosine-1-phosphate (S1P) transporter Spns2 (with an IC50 of 94 nM for the mouse transporter), selectively reduces circulating lymphocyte counts without altering plasma S1P concentrations in mice at a dosage of 10 mg/kg.

SLF1081851 (hydrochloride), a Spns2 inhibitor, effectively inhibits S1P release with an IC50 value of 1.93 μM. This compound is instrumental in the development and functioning of the immune system [1].

SLF80821178 hydrochloride is an orally active anticancer compound that effectively targets the inhibitory function of Spns2 (sphingosine-1-phosphate transporter) and can significantly reduce the release of sphingosine-1-phosphate (S1P) in HeLa cells. Has an IC50 value of 51 nM. Furthermore, SLF80821178 hydrochloride effectively reduced circulating lymphocyte levels in a mouse model without significant effects on plasma S1P levels.

SLF80821178 is a potent and orally active inhibitor of sphingosine-1-phosphate transporter (Spns2). It inhibits S1P release in HeLa cells with an IC50 of 51 nM and has a half-life of 2.4 hours in mice.