spergualin

Spergualin trihydrochloride is a natural product that first identified as an antibiotic from culture filtrates of Bacillus laterosporus BMG162-aF2[1]. Spergualin trihydrochloride derivatives likely acts as Hsp70 modulators[1]. [1]. Srikanth Patury, et al. Pharmacological Targeting of the Hsp70 Chaperone. Curr Top Med Chem. 2009;9(15):1337-51.

(-)-15-Deoxyspergualin is a potent antitumor agent that significantly inhibits mouse leukemia L-1210.

(-)-15-Deoxyspergualin trihydrochloride exhibits potent antitumor properties and demonstrates significant inhibition activity against mouse leukemia L-1210 [1].

Gusperimus trihydrochloride is a derivative of the antitumor antibiotic spergualin with immunosuppressant activity.

Gusperimus was synthesized by chemical modification of spergualin and in combination with cyclosporine A to prevent diabetes in susceptible NOD mice.