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By Target- CRM1
- NF-κB(1)
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Results for "
sp-100030
" in TargetMol Product Catalog- Inhibitors & Agonists2
SP-100030
SP100030, SP 100030
T24816154563-54-9
SP-100030 is a dual inhibitor of NF-κB and activator protein-1 (AP-1), demonstrating potent inhibition with IC50 values of 50 nM for both. It effectively reduces the production of IL-2, IL-8, and TNF-alpha in Jurkat and other T cell lines. Additionally, SP-100030 has been shown to decrease the severity of murine collagen-induced arthritis (CIA).
- $30
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QTY
SP100030 analogue 1
T89990154934-68-6
SP100030 analogue 1 (compound 11) is a selective transcription activation (SITA) inhibitor within the SP100030 class, capable of inhibiting XPO1-dependent upregulation of IL2 in a Jurkat-based IL2-Luc reporter assay, with an EC50 of 137 nM.
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