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Results for "
sofnobrutinib
" in TargetMol Product Catalog- Inhibitors & Agonists1
Sofnobrutinib
AS-0871
T728651646608-10-7
Sofnobrutinib (AS-0871) is an orally active, selective inhibitor of Bruton's tyrosine kinase (BTK) with IC50 values of 4.2 nM for activated BTK and 0.39 nM for unactivated BTK. It has an IC50 of 24 μM against hERG, exhibits strong metabolic stability and bioavailability, induces a weak passive cutaneous anaphylaxis reaction, and demonstrates anti-inflammatory properties in a mouse model of collagen-induced arthritis.
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