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By Target- HMG-CoA Reductase
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Results for "
sk&f 99085
" in TargetMol Product Catalog- Inhibitors & Agonists1
Apomine
SK&F-99085, APB-231-A2, APB-231-A-2, SR-9223i, SK&F-99085, SR-45023A
T26644126411-13-0In house
Apomine (SR-9223i), an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and has been implicated in the regulation of myeloma in vivo. Apomine accelerates the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase and stimulates low-density lipoprotein receptor activity. Apomine enhances the antitumor effect of lovastatin on myeloma cells by downregulating 3-hydroxy-3-methylglutaryl-CoA reductase.
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