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shmt2

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  • Inhibitors & Agonists
    4
    TargetMol | Inhibitors_Agonists
(Rac)-SHIN2
T729842204289-53-0In house
(Rac)-SHIN2, a serine hydroxymethyltransferase (SHMT) inhibitor, enhances NOTCH1-driven in vivo survival of primary T-ALL in mice and is useful for studying T-cell acute lymphoblastic leukemia (T-ALL).
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6-8 weeks
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SHIN1
RZ-2994
T12897L2146095-85-2
SHIN1 (RZ-2994) is an inhibitor of human serine hydroxymethyltransferse 1(SHMT1) with IC50 of 5 nM and human serine hydroxymethyltransferse 2 (SHMT2) with an IC50 of 13 nM.
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TargetMol | Citations Cited
SHMT-IN-3
T203417330638-43-2
SHMT-IN-3 (Hit 1) is an inhibitor of SHMT1 and SHMT2, exhibiting an IC50 value of 0.53 µM for human SHMT1. It acts as a non-competitive inhibitor with respect to serine.
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SHMT-IN-2
T624042102681-49-0
SHMT-IN-2 (compound 2) is a specific human SHMT1 2 small molecule inhibitor that acts on SHMT1 (IC50: 13 nM) and SHMT2 (IC50: 66 nM). SHMT-IN-2 inhibits the growth of many human cancer cells and is sensitive to B-cell lymphoma.
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6-8 weeks
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