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sec61 in 1

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  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
Sec61-IN-1
Sec61-IN-1
T401462484865-42-9
Sec61-IN-1, a powerful Sec61 inhibitor, impedes the translocation of proteins across the endoplasmic reticulum membrane.
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Sec61-IN-5
T81183
Sec61-IN-5 (Compound 16c), a Sec61 inhibitor, exhibits cytotoxicity in A549 cells with an IC50 of 0.27 nM and impedes Sec61-dependent secretory function with an IC50 of 0.08 nM [1].
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Sec61-IN-4
T81184
Sec61-IN-4 (Compound 16b) is a potent inhibitor of Sec61, exhibiting an IC50 value of 0.04 nM in U87-MG cells [1].
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Cotransin
TP2563863753-73-5
Cotransin, a Sec61 translocation inhibitor, selectively prevents the stable insertion of certain nascent chains into the Sec61 translocation channel, exhibiting signal-sequence discrimination. This compound also inhibits the expression of VCAM-1 and p-selectin proteins by blocking their co-translational translocation across endoplasmic reticulum (ER) membranes (IC 50 =0.5-5 µM). Cotransin's role extends to potential applications in inflammation and immunity research [1] [2].
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