saikogenin d

Saikogenin D possesses dual mechanisms of action including inhibition of A23187-induced PGE2 production without direct cyclooxygenase suppression, and stimulation of intracellular calcium elevation through Ca2+ release from internal stores, while further displaying immunomodulatory properties demonstrated by its ability to attenuate IL-6 production in LPS-stimulated alveolar macrophages from B6 mice more strongly than in BALB mice, highlighting selective regulation of inflammatory responses.

Prosaikogenin D (Prosapogenin D) is a natural product extracted from the roots of Buleurum bicaule Helm (Apiaceae) with anti-cancer activity.