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s 0960

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  • Inhibitors & Agonists
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S 0960
S0960
T70688142974-51-4In house
S 0960 is a dimeric bile acid analog, a specific inhibitor of the sodium-dependent bile salt transporter in the ileum, used in metabolic disease research.
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10-14 weeks
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HJC-0123
T706861430420-02-2
Downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significantly suppressed estrogen receptor (ER)-negative breast cancer MDA-MB-231 xenograft tumor growth in vivo (p.o.), indicating its great potential as an efficacious and orally bioavailable drug candidate for human cancer therapy.
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6-8 weeks
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