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ro 5068760

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RO5068760
T68267947182-25-4
RO5068760 , a substituted hydantoin, is a potent, highly selective, non-adenosine triphosphate (ATP)-competitive MEK1 2 inhibitors. RO5068760 shows significant efficacy in a broad spectrum of tumors with aberrant mitogen-activated protein kinase pathway activation. In vitro, RO5068760 demonstrates MEK1 kinase inhibitory activity with an IC50 of 0.025 μM in a cRaf MEK ERK cascade assay RO5068760 showed superior efficacy in tumors harboring B-RafV600E mutation.
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8-10 weeks
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