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By Target- Topoisomerase
- ADC Cytotoxin(1)
- Antibiotic(1)
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Results for "
rebeccamycin
" in TargetMol Product Catalog- Inhibitors & Agonists2
- Natural Products1
- ADC/ADC Related1
Rebeccamycin
T1672693908-02-2
Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II.
- $445
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QTY
Becatecarin
T36485119673-08-4
Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2.
- $535
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