rat nnos

GW274150 is an orally active, selective and potent dual inhibitor of NADPH-dependent human nitric oxide synthase (iNOS) (Kd=40 nM) and rat inducible nitric oxide synthase (iNOS).GW274150 has a low activity against endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthase (nNOS) in humans and rats. GW274150 showed protective effects in an inflammatory model of acute lung injury.

2-Iminobiotin hydrobromide (Guanidinobiotin) is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS, respectively).

L-NMMA acetate (Tilarginine acetate) is an inhibitor of nitric oxide synthase of all NOS isoforms (i.e. NOS1, NOS2, and NOS3). The Ki values are 0.18, 0.4, and 6 µM for nNOS, eNOS, and iNOS, respectively.

2-Iminobiotin (Guanidinobiotin) is a cyclic guanidino analog of biotin and serves as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS), with Ki values of 21.8 μM for mouse iNOS and 37.5 μM for rat nNOS.

GW274150 (dihydrochloride) is a potent and selective inhibitor of human and rat inducible nitric oxide synthase (iNOS), exhibiting oral activity and NADPH-dependence with an IC50 of 2.19 μM and Kd of 40 nM for human iNOS, and an ED50 of 1.15 μM for rat iNOS. It demonstrates reduced effectiveness against endothelial NOS (eNOS) and neuronal NOS (nNOS) in both species, and has shown protective effects in acute lung injury inflammation models [1] [2] [3].