radiation sensitizer

Misonidazole as a novel GPX inhibitors to cause oxidative stress in chemotherapy-resistant tumors.

Protoporphyrin IX disodium, as a radiation sensitizer, enhances the production of ROS and induces DNA damage even under hypoxic conditions. It also acts as a photosensitizer, undergoing direct degradation through photobleaching upon light exposure. This compound accumulates in rat tumor cells following administration of 5-aminolevulinic acid (5-ALA). When activated with a peak wavelength of 405 nm, Protoporphyrin IX disodium selectively improves basal cell carcinoma. It shows promise in pharmacological research of sonodynamic and photodynamic therapy for cancers such as bladder cancer and nodular basal cell carcinoma.

Nimorazole (Nimorazol) is a nitroimidazole anti-infective.

Isometronidazole (RO-07-1502) is a chemical compound. The chemical compound is a derivative of the nitroimidazole family. Its molecular formula is C6H9N3O3. Isometronidazole can actually be used in the treatment of radiation therapy. The compound is known as a hypoxic cell sensitizer (radiosensitizer), increasing the efficacy of radiation treatment. Isometronidazole (RO-07-1502), a nitroimidazole derivative with the molecular formula C6H9N3O3, acts as a hypoxic cell sensitizer (radiosensitizer) in radiation therapy, enhancing the efficacy of the treatment.

Irisquinone, a natural anticancer agent, also acts as a radiation sensitizer for cancer therapies. It diminishes glutathione (GSH) levels and hampers the repair of single-strand DNA breaks [1] [2] [3].