r 18

Antagonist of 14.3.3 proteins (KD ≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S.

R18 TFA, a peptide antagonist of 14-3-3, exhibits a dissociation constant (K_D) of 70-90 nM. It efficiently inhibits the interaction between 14-3-3 and its physiological ligand, the kinase Raf-1, thereby significantly impeding the protective effect of 14-3-3 on Raf-1 against phosphatase-induced deactivation [1].

17(18)-EpETE is a 17(18)-epoxy-eicosatetraenoic acid and a metabolite of Eicosapentaenoic acid. It can stimulate outward potassium ion currents and has a relaxing effect on human pulmonary artery and airway smooth muscles.

17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid. 17R(18S)-EpETE activates large-conductance calcium-activated potassium (BKCa) channels, increasing potassium current amplitude by 15-fold in isolated rat cerebral artery vascular smooth muscle cells at +60 mV at 50 nM. 17R(18S)-EpETE also exerts negative chronotropic effects in neonatal rat cardiomyocytes with an EC50 of ~1–2 nM and prevents calcium-induced increases in spontaneous beating. 17R(18S)-EpETE is therefore used in cardiovascular electrophysiology research systems to investigate ion channel modulation, lipid mediator signaling, and cardiac excitability regulation in cellular models.

18:1 Hemi BMP (S,R) is a reagent used in biochemical reactions.

18:1 BMP (R,R'; 2,2'-isomer) ammonium is a bis(monoacylglycerol) phosphate (BMP).

18:1 BMP (R,R) ammonium is a bis(monoacylglycerol) phosphate (BMP) compound.

18:1 BMP (S,R) ammonium is a bis(monoacylglycerol) phosphate (BMP).

(R)-SL18 is a degrader of ANXA3 that facilitates its breakdown via ubiquitination. This compound can inhibit the proliferation, migration, invasion, and colony formation of breast cancer cells, while also inducing apoptosis. (R)-SL18 is applicable for research in triple-negative breast cancer.

CSF1R-IN-18 (Compound 16t) is an aniline derivative that acts as an inhibitor of the colony stimulating factor 1 receptor (CSF1R). It is applicable in research related to cancer, central nervous system disorders, and bone diseases.

C24 (2'(R)-hydroxy) dihydro Ceramide (d18:0/24:0) is a lipid molecule that can be used in life science related research. The CAS number of C24 (2'(R)-hydroxy) dihydro Ceramide (d18:0/24:0) is 164989-36-0.

GLP-1R agonist 18 (example 117) acts as an agonist at GLP-1R, exhibiting an EC50 of 0.044 nM [1].

(20R)-18,20-Epoxydigitoxigenin-alpha-L-thevetoside is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(8R,12S)-3,8,12,17-tetrahydroxytricyclo[12.3.1.1^{2,6}]nonadeca-1(18),2,4,6(19),14,16-hexaen-9-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

TAT-PAK18 R192A is an inactive Tat-Pak peptide. It does not influence Rac1 translocation triggered by any tested proteins.

(3R,15Z,18Z,21Z,24Z,27Z)-3-Hydroxytriacontapentaenoyl-CoA ((3R,15Z,18Z,21Z,24Z,27Z)-3-Hydroxytriacontapentaenoyl-coenzyme A) is an unsaturated fatty acyl-CoA.

(3R,6Z,9Z,12Z,15Z,18Z)-3-Hydroxytetracosapentaenoyl-CoA ((3R,6Z,9Z,12Z,15Z,18Z)-3-Hydroxytetracosapentaenoyl-coenzyme A) is a derivative of coenzyme A.

(3R,15Z,18Z,21Z,24Z)-3-Hydroxytriacontatetraenoyl-CoA ((3R,15Z,18Z,21Z,24Z)-3-Hydroxytriacontatetraenoyl-coenzyme A) is a type of 3-hydroxy fatty acyl-CoA.

(3R,9Z,12Z,15Z,18Z)-3-Hydroxytetracosatetraenoyl-CoA ((3R,9Z,12Z,15Z,18Z)-3-Hydroxytetracosatetraenoyl-coenzyme A) is a form of 3-hydroxy fatty acyl-CoA.

(3R,9Z,12Z,15Z,18Z,21Z)-3-Hydroxytetracosapentaenoyl-CoA [(3R,9Z,12Z,15Z,18Z,21Z)-3-Hydroxytetracosapentaenoyl-coenzyme A] is a type of unsaturated fatty acyl-CoA.

(3R,6Z,9Z,12Z,15Z,18Z,21Z)-3-Hydroxytetracosahexaenoyl-CoA ((3R,6Z,9Z,12Z,15Z,18Z,21Z)-3-Hydroxytetracosahexaenoyl-coenzyme A) is a derivative of coenzyme A.

(3R,18Z,21Z,24Z,27Z,30Z,33Z)-3-Hydroxyhexatriacontahexaenoyl-CoA ((3R,18Z,21Z,24Z,27Z,30Z,33Z)-3-Hydroxyhexatriacontahexaenoyl-coenzyme A) is an unsaturated acyl-coenzyme A.

C24:0(2R-OH) Mono-sulfo galactosyl(β) ceramide (d18:1/24:0) is a type of 2-hydroxyceramide.

USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]. Arthur F Kluge, et al. Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg Med Chem Lett. 2018 Aug 15;28(15):2655-2659.