quality-control

N-Phenethylacetamide is an amide derivative of phenethylamine that can be used as a reference standard for quality control and analytical testing, and it can also be employed as an effective antimicrobial agent for use in aquaculture systems.

Guanosine (Standard) is a standard preparation of guanosine, suitable for quantitative analysis, quality control, and biochemical experiments. Guanosine is a nucleotide composed of the purine base guanine, ribose, and phosphate groups, and is a constituent of RNA.

Isopentyl 3-(4-methoxyphenyl)acrylate (Standard) is a reference standard for Isopentyl 3-(4-methoxyphenyl)acrylate, suitable for quantitative analysis, quality control, and biochemical experiments. Isopentyl 3-(4-methoxyphenyl)acrylate functions as an ultraviolet filter.

Compound STOCK1N-76738 is a standardized research reagent specially for designed for quality control and verification. it has a stable chemical structure and clear adaptability to biochemical reactions.

Terbuthylazine is a triazine herbicide and a selective acetolactate synthase (ALS) inhibitor, toxic to aquatic organisms, and capable of disrupting gut microbiota. Terbuthylazine induces significant damage to the jejunal barrier and mitochondrial quality control imbalance.

AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3]. Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts[1]. [1]. Ryosuke Nomura, et al. Azidothymidine-triphosphate Impairs Mitochondrial Dynamics by Disrupting the Quality Control System. Redox Biol. 2017 Oct;13:407-417. [2]. Takeya Sato, et al. Engineered Human tmpk/AZT as a Novel Enzyme/Prodrug Axis for Suicide Gene Therapy. Mol Ther. 2007 May;15(5):962-70. [3]. K Y Hostetler, et al. Enhanced Oral Absorption and Antiviral Activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and Related Compounds in Hepatitis B Virus Infection, in Vitro. Biochem Pharmacol. 1997 Jun 15;53(12):1815-22.

Oroxylin A 7-O-β-d-glucuronide and wogonoside should also be served as the chemical markers together with baicalin for the quality control of herbs and proprietary traditional Chinese medicine (PTCM) products of radix Scutellariae. Oroxylin A 7-O-glucuronide, Oroxin A, and Oroxin B can bind to the "stem" region of α-hemolysin (α-HL), when inhibiting the hemolytic activity of α-HL. Oroxylin A 7-O-glucuronide and 4', 5, 7-trihydroxy-6-methoxyflavone at a concentration of 100 microM inhibit 34 and 43% of total prolyl oligopeptidase (POP) activity, respectively.

FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.

1. Albiflorin (Alibiflorin) has anticonvulsant effect for pain relief. 2. Albiflorin and paeoniflorin has neuroprotective action against Glu toxicity. 3. Albiflorin and paeoniflorin significantly ameliorated Glu-induced reduction of cell viability, nuclear and mitochondrial apoptotic alteration, reactive oxygen species accumulation and B-cell lymphoma 2 (Bcl-2)/Bax ratio. 4. Albiflorin can serve as a new chemical marker for the quality control of Paeoniae Radix and the Chinese Pharmacopoeia can be updated, via has similar anti-inflammatory effects to paeoniflorin.

1. Alisol A 24-acetate (Alisol A monoacetate) has been determined for the quality control of this crude drug.

Wilforlide A (T1) serves as a quality control standard of Tripterygium Glycosides that be listed in Drug Standard of Ministry of Public Health of the People's Republic of China. T1 has anti-inflammatory effects.

(-)-Menthol (Standard) is the standard substance of (-)-Menthol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. (-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foods, menthol functions as a fortifier for peppermint flavors. It also has a counterirritant effect on skin and mucous membranes, thereby producing a local analgesic or anesthetic effect.

(±)-1,2-Propanediol (Standard) is the standard substance of (±)-1,2-Propanediol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. (±)-1,2-Propanediol is an aliphatic alcohol that has a variety of roles as a preservative and antifreeze, and has a wide range of applications in the food industry and skin care industry. (±)-1,2-Propanediol is a natural bacteriostatic agent that inhibits the growth and multiplication of bacteria to a certain extent.

(±)-Diclofop (Standard) is the standard substance of (±)-Diclofop, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. (±)-Diclofop is an Acetyl-CoA carboxylase (ACCase) inhibiting herbicide.

(±)-Indoxacarb (Standard) is the standard substance of (±)-Indoxacarb, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. (±)-Indoxacarb is a pyrazoline insecticide with insecticidal activity and cytotoxicity, blocks sodium channels in insect neurons, and can induce apoptosis.

(±)-Leucine (Standard) is the standard substance of (±)-Leucine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. (±)-Leucine (DL-2-Aminmo-4-methylvalerianic acid) can be found in Green bell peppers, Green zucchinis, Italian sweet red peppers, and Red bell peppers.

(2,6-Dichlorophenyl)methanol (Standard) is the standard substance of (2,6-Dichlorophenyl)methanol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. (2,6-Dichlorophenyl)methanol is a useful organic compound for research related to life sciences. The catalog number is T66709 and the CAS number is 15258-73-8.

(3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one (Standard) is the standard substance of (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. (3S,4R,5S)-1,3,4,5,6-Pentahydroxyhexan-2-one (L(-)-Sorbopyranose) is a ketose belonging to the group of sugars known as monosaccharides.

(L)-Sodium lactate (Standard) is the standard substance of (L)-Sodium lactate, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. (L)-Sodium lactate (Sodium L-Lactate) is produced from pyruvate by the enzyme Lactate Dehydrogenase. Lactate production occurs during anaerobic glycolysis or in proliferatively active cells. L-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity. L-Lactic acid is also present in liver, kidney, thymus gland, human amniotic fluid, and other organs and body fluids.

(S)-Malic acid (Standard) is the standard substance of (S)-Malic acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a tart-tasting organic dicarboxylic acid that plays a role in many sour or tart foods. Apples contain malic acid, which contributes to the sourness of a green apple. Malic acid can make a wine taste tart, although the amount decreases with increasing fruit ripeness. (wikipedia). In its ionized form malic acid is called malate. Malate is an intermediate of the TCA cycle along with fumarate. It can also be formed from pyruvate as one of the anaplerotic reactions. In humans, malic acid is both derived from food sources and synthesized in the body through the citric acid cycle or Krebs cycle which takes place in the mitochondria. Malate's importance to the production of energy in the body during both aerobic and anaerobic conditions is well established. Under aerobic conditions, the oxidation of malate to oxaloacetate provides reducing equivalents to the mitochondria through the malate-aspartate redox shuttle. During anaerobic conditions, where a buildup of excess of reducing equivalents inhibits glycolysis, malic acid's simultaneous reduction to succinate and oxidation to oxaloacetate is capable of removing the accumulating reducing equivalents. This allows malic acid to reverse hypoxia's inhibition of glycolysis and energy production. In studies on rats it has been found that only tissue malate is depleted following exhaustive physical activity. Other key metabolites from the citric acid cycle needed for energy production were found to be unchanged. Because of this, a deficiency of malic acid has been hypothesized to be a major cause of physical exhaustion. Notably, the administration of malic acid to rats has been shown to elevate mitochondrial malate and increase mitochondrial respiration and energy production.

(S)-Metolachor (Standard) is the standard substance of (S)-Metolachor, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. (S)-Metolachor （(S)-Metolachlor） is a carcinogenic insecticide, a derivative of aniline, and is a frequent subject of research in agriculture and environmental protection.

1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol (Standard) is the standard substance of 1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol is a useful organic compound for research related to life sciences. The catalog number is T65156 and the CAS number is 24155-42-8.

1,1,1,1-Kestohexaose (Standard) is the standard substance of 1,1,1,1-Kestohexaose, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 1,1,1,1-Kestohexaose (1,1,1,1-Kestohexose) is a natural product isolated from Poa ampla.

1,2,3-Trieicosapentaenoyl-rac-glycerol (Standard) is the standard substance of 1,2,3-Trieicosapentaenoyl-rac-glycerol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 1,2,3-Trieicosapentaenoyl-rac-glycerol (EPA-TG) is a glycerol ester of eicosapentaenoic acid , which is an ω-3 fatty acid. An EPA-TG emulsion, administered i.v., lowers leukotriene B4 production by 40% in polymorphonuclear leukocytes from rabbits and reduces platelet aggregation. It suppresses natural killer cell activity both in vitro and in vivo, in human lymphocytes and murine spleens, respectively, with the in vivo effects lasting up to seven days.