pyrazolopyridine

BMS-265246 is a potent and selective CDK1/2 inhibitor. Its chemical name is (4-[R-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-1H-indol-1-yl]-1H-pyrazolo[3,4-d] pyrimidine-6-amine), and it functions by targeting CDK1 and CDK2 to potentially disrupt cell cycle progression.

ML303 is an antagonist of pyrazolopyridine influenza virus nonstructural protein 1 (NS1) (IC90 : 155 nM).

CDK2-IN-51 is a pyrazolopyridine derivative and acts as a CDK2 inhibitor with an IC50 of 23.47 nM. It reduces the expression of DNA replication factors (Polα, MCM7, ORC2, and ORC4) and causes cell cycle arrest before the G1 phase. CDK2-IN-51 does not induce apoptosis and does not significantly affect CDK2 protein expression. This compound is applicable in colorectal cancer research.

FK-352 is a pyrazolopyridine derivative and adenosine-1 receptor antagonist.