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By Target- Monoamine Oxidase
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Results for "
pxs5153a
" in TargetMol Product Catalog- Inhibitors & Agonists2
PXS-5153A monohydrochloride
PXS-5153A monohydrochloride (2125956-82-1 free base)
T12585L
PXS-5153A monohydrochloride is a potent, selective, orally active and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor, with an IC 50 of <40 nM for LOXL2 across all mammalian species and an IC 50 of 63 nM for human LOXL3. PXS-5153A monohydrochloride dose-dependently reduced LOXL2-mediated collagen oxidation and collagen crosslinking in vitro which may represent an innovative therapeutic approach for the treatment of fibrosis
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