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pt-2399

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  • Inhibitors & Agonists
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    TargetMol | All_Pathways
(Rac)-PT2399
T126751672662-07-5
(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).
  • $347
10-14 weeks
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PT2399
T12675L1672662-14-4
PT2399 is a potent, selective, orally available HIF-2α antagonist that directly binds to the PAS B domain of HIF-2α (IC₅₀ = 6 nM). PT2399 exhibits antitumor activity. PT2399 specifically blocks the heterodimerization of HIF-2α and HIF-1β, thereby inhibiting the expression of downstream target genes such as VEGF and GLUT1, and exerts its antitumor effects.
  • $95
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