psychostimulant

Ordopidine (ACR325) is a dopaminergic stabilizer that suppresses psychostimulant-induced hyperactivity disorder and stimulates behavior during inactivity. Ordopidine acts as a dopamine D2 receptor antagonist in vitro and, despite its low affinity, its specific state-dependent behavioral effect characteristics are not generally shared by D2 receptor antagonists.

Metapramine (19560 RP) is a novel psychostimulant, an N-methyl-D-aspartate receptor (NMDA) antagonist with antidepressant and anti-injury perception activity that promotes increased levels of acetylcholine in the striatum.

Thozalinone is a psychostimulant agent inducing the release of norepinephrine and dopamine.

Phenprobamate (MH 532) is a relaxant that acts on central skeletal muscle and has anticonvulsant and psychostimulant effects.

1. Pulegone ((+)-Pulegone) has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a verapamil-sensitive psychostimulant effect that appears to independ on the opening of L-type calcium channels. 3. Pulegone has negative reinforcing properties and seems to possess anxiolytic-like actions unrelated to the benzodiazepine site of the γ-aminobutyric acid type A (GABAA) receptor.

Diphenylpyraline hydrochloride (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) is used in the treatment of Parkinsonism.It is a first-generation antihistamine with anticholinergic effects, functions as a dopamine reuptake inhibitor.

OS-3-106 is a novel arylamide phenylpiperazines, as partial agonists at the D3R in the adenylyl cyclase inhibition assay.

RO5256390 is a trace amine-associated receptor 1 (TAAR1) agonist, a highly conserved G-protein-coupled receptor that blocks psychostimulant-induced hyperarousal, and may be used in the study of neurological disorders.

Pimeclone hydrochloride is a psychostimulant or a respiratory stimulant drug.

JJC8-088, a potent DAT inhibitor, is derived from Modafinil and serves as a novel ligand. This compound is utilized in research on psychostimulant use disorders [1].

JJC8-091 is a powerful DAT inhibitor, useful for researching psychostimulant use disorders [1].

SB 206553 is a 5-HT2C inverse agonist that can attenuate methamphetamine-seeking behavior in rats. It exhibits activity for 5-HT2 receptor ligands with pKi values of 5.6 nM (5-HT2A), 7.7 nM (5-HT2B), and 7.8 nM (5-HT2C) in HEK-293 or CHO-K1 cells expressing human recombinant 5-HT2 receptors. SB 206553 can be used for research into psychostimulant abuse disorders [1].

PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM).