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pst-2774

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  • Inhibitors & Agonists
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Phenamil
T699742038-35-9
Phenamil is an inhibitor of epithelial sodium channels, which activates the osteomorphin protein signalling pathway to promote bone repair and induces significant fat formation.
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Phenamil methanesulfonate
T231481161-94-0
Phenamil methanesulfonate is a potent analog of Amiloride that functions as a strong and less reversible epithelial sodium channel (ENaC) blocker with an IC50 of 400 nM, Phenamil methanesulfonate also acts as a competitive inhibitor of TRPP3 and suppressing TRPP3-mediated calcium transport with an IC50 of 140 nM in Ca2+ uptake assays. Phenamil methanesulfonate robustly activates BMP signaling to promote bone repair, supporting its use in cystic fibrosis lung disease, ion channel biology, and regenerative medicine research.
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