propargyl-peg3-azide

Propargyl-PEG3-amine is a PEG derivative containing a propargyl group and an amino group. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper-catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.

Azido-PEG3-S-PEG4-propargyl is a polyethylene glycol (PEG)-based linker containing azide and propargyl groups, designed specifically for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Amino-PEG4-bis-PEG3-propargyl functions as a cleavable 6-unit PEG ADC linker in the creation of antibody-drug conjugates (ADCs) [1]. As a click chemistry reagent, it features an Alkyne group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with Azide-containing molecules.