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- DNA/RNA Synthesis(1)
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Results for "
procarbazine hydrochloride
" in TargetMol Product Catalog- Inhibitors & Agonists1
Procarbazine hydrochloride
NSC-77213 HCl, Procarbazine HCl
T1488366-70-1
Procarbazine hydrochloride (NSC-77213 HCl) is the hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.
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Ro 4-6467/1, Ro 4-6467, Procarbazine, NSC-77213, CB 400-497
T1488L671-16-9
Procarbazine is an antineoplastic chemotherapy drug for the treatment of Hodgkin's lymphoma and certain brain cancers. The drug is metabolized and activated in the liver. It also inhibits MAO thus increasing the effects of sympathomimetics, TCAs, and tyra
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