pl017

Selective μ opioid receptor agonist (IC50 values are 5.5 and > 10000 nM for inhibition of 125I-FK 33,824 and 125I-DADLE binding to μ and δ sites respectively). Produces naloxone-reversible analgesia, catalepsy and hyperthermia following central administra

1H-pyrrolo[2,3-c]pyridin-5-amine ,with CAS No. 174610-12-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1H-pyrrolo[2,3-c]pyridin-5-amine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

PL-017 TFA, a potent and selective μ-opioid receptor agonist, displays significant affinity with an IC50 of 5.5 nM for 125I-FK 33,824 binding to the μ-site. This compound is effective in producing long-lasting, reversible analgesia in rats [1].