phencyclidine

JNJ-37822681 has potential for the treatment of schizophrenia and bipolar disorder.JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2

3,4-Methylenedioxy pcp hydrochloride (3,4-MDPCP hydrochloride; 3,4-Methylenedioxy phencyclidine hydrochloride) is a drug derivative used in the study of psychiatric disorders.

3-Methyl phencyclidine hydrochloride is an arylcyclohexylamine compound known for its psychoactive properties.

PCEEA hydrochloride is a psychoactive compound structurally similar to eticyclidine, ketamine, and phencyclidine.

Metaphit methylsulfate is a specific PCP antagonist and an acylating agent for the [3H] phencyclidine binding site in rat brain homogenate. It inhibits PCP-induced motor activity through a presynaptic mechanism.

BD-1047 is a selective functional antagonist of sigma receptors. It can alleviate climbing behavior induced by Apomorphine and head twitching caused by Phencyclidine.

3-Methoxyeticyclidine hydrochloride is a phencyclidine analog with affinity for N-methyl-D-aspartate (NMDA) receptors. It possesses a certain level of toxicity.

PZ-1657 (Compound 57) is an orally active inverse agonist of the 5-HT7 receptor (5-HT7 receptor), with high selectivity, ability to penetrate the blood-brain barrier, and metabolic stability, demonstrating a Ki value of 5 nM. It effectively inhibits Gs pathway-mediated basal cyclic adenosine monophosphate (cAMP) production, with an EC50 value of 2.93 nM. Additionally, PZ-1657 inhibits CYP3A4P450 (IC50 = 12.2 μM) and affects the hERG channel. This compound also reduces MMP-9 activity mediated by the 5-HT7 receptor and reverses cognitive dysfunction induced by Phencyclidine. PZ-1657 exhibits antidepressant properties.

PZ-1657 hydrochloride (Compound 57) is a potent, selective, and orally active 5-HT7 receptor inverse agonist, with a Ki value of 5 nM. It inhibits constitutive cAMP production mediated by the Gs signaling pathway, with an EC50 value of 2.93 nM. PZ-1657 hydrochloride significantly reduces 5-HT7 receptor-mediated MMP-9 activity in the mouse hippocampus, showing effects comparable to SB-269970. It reverses cognitive deficits induced by phencyclidine in a rat novel object recognition test without affecting spontaneous activity. PZ-1657 hydrochloride is useful for researching affective disorders such as depression and bipolar disorder.

2-Phenyl-2-(1-piperidinyl)propane (PPP), an analog of phencyclidine, is a chemical compound.

Compound 16, also known as 25N-N1-Nap, functions as a β-arrestin-biased 5-HT2A agonist. It effectively antagonizes phencyclidine-induced hyperactivity in male C57BL/6J mice [1].

CBiPES, a potent mGlu2 positive allosteric modulator with an EC50 value of 92.8 nM, attenuates stress-induced hyperthermia and Phencyclidine-induced hyperlocomotor activity, and can be used for research of neurological diseases [1] [2].