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Results for "
pf-04577806
" in TargetMol Product Catalog- Inhibitors & Agonists1
PF-04577806
T384621072100-81-2
PF-04577806 is a potent, selective, and ATP-competitive inhibitor of protein kinase C (PKC), showing significant inhibitory activity against various PKC isoforms, including PKCα (IC50=2.4 nM), PKCβI (IC50=8.1 nM), PKCβII (IC50=6.9 nM), PKCγ (IC50=45.9 nM), and PKCθ (IC50=29.5 nM). Additionally, it can reverse retinal vascular leakage in diabetic rats.
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