peptidyl transferase

Azidamfenicol inhibits ribosomal peptidyltransferase with a Ki of 22 µM. Azidamfenicol is a broad-spectrum chloramphenicol-like antibiotic.

Levomecol, a broad-spectrum antibiotic derived from Streptomyces venezuelae, comprises Chloramphenicol and Methyluracil. It exerts its bacteriostatic effect by binding to the bacterial ribosome, inhibiting protein synthesis by blocking peptidyl transferase.

Valnemulin hydrochloride (Valnemulin HCl) is a broad-spectrum bacteriostatic agent inhibiting protein synthesis in bacteria by binding to the peptidyl transferase component of the 50S subunit of ribosomes.

Lefamulin acetate (BC-3781 acetate) (formally BC-3781 acetate) is a novel pleuromutilin antibiotic and is the first to be used for the systemic treatment of bacterial infections in humans. Lefamulin acetate (BC-3781 acetate) inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, preventing the binding of transfer RNA for peptide transfer. Lefamulin acetate (BC-3781 acetate) is an orally active antibiotic for community-acquired bacterial pneumonia (CABP) treatment.

Anti-MRSA agent 20 (Compound a4) is an antimicrobial agent targeting MRSA with a minimum inhibitory concentration (MIC) of less than 0.03125 μg/mL. It binds to the peptidyl transferase center of the ribosome, inhibiting the synthesis of MRSA toxins and bacterial division, thereby suppressing bacterial survival. Furthermore, Anti-MRSA agent 20 significantly reduces the pulmonary MRSA load and diminishes lung damage in mice infected with MRSA (ED50= 6.48 mg/kg).

Antibacterialagent 301 (compound 14c) is a pyridinecarboxamide derivative of pleuromutilin, exhibiting broad-spectrum antibacterial activity as well as significant antimycoplasmal effects. It inhibits the peptidyl transferase center (PTC), disrupts biofilms, and damages the cell membranes of multi-drug resistant (MDR) bacteria. In a murine model of systemic methicillin-resistant Staphylococcus aureus (MRSA) infection, Antibacterialagent 301 demonstrated efficacy. It can be used in research on multi-drug resistant bacterial infections.

Valnemulin, a broad-spectrum pleuromutilin antibiotic, targets peptidyl transferase within the 50S ribosomal subunit, effectively used in veterinary medicine to address swine diseases such as B. hyodysenteriae and M. hyopneumoniae.

Trichodermin is a naturally occurring sesquiterpene antibiotic (antibiotic) and a powerful inhibitor of protein synthesis (protein synthesis). It binds to eukaryotic ribosomes, inhibiting protein translation by interacting with peptidyl transferase. Trichodermin suppresses oral cancer growth by inducing apoptosis (apoptosis)-related mitochondrial dysfunction and HDAC-2-mediated signaling. It exhibits potent antimicrobial activity against filamentous fungi, yeasts, and bacteria.

Albomycin δ1 is a selectively targeting bacterial ribosome antibiotic (antibiotic) with a minimum inhibitory concentration (MIC) of 0.0625 μg/mL against S. pneumoniae. It exerts its bactericidal effect by covalently binding to the 70S ribosome and irreversibly inhibiting peptidyl transferase. Albomycin δ1 holds promise for research on infections caused by S. pneumoniae and S. aureus.

(Rac)-Bromamphenicol is the racemic mixture of Bromamphenicol. Bromamphenicol (Compound Ib) is a derivative of Chloramphenicol with antibacterial properties. It binds to the S50 ribosomal subunit, disrupting peptidyl transferase activity, and exhibits inhibitory effects on protein synthesis.