parp1-in-8

PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) is an effective inhibito of PARP1 (IC50 = 97 nM).

PARP1-IN-37 (Compound 8) is an orally active and selective inhibitor of poly (ADP-ribose) polymerases 1 and 2 (PARP1/2), with an IC50 value of 24 nM for PARP1. It inhibits PARP activity in cells with an EC50 value of 3.7 μM and holds potential for research on BRCA-mutated tumors, such as breast and ovarian cancers.

8-ET-NAD+ (sodium) is a derivative of NAD+ and is utilized for screening PARP1 gate mutations. It is also applicable in cancer research.

8-DMA-NAD+ (sodium) (8-Dimethylamino-NAD+ (sodium)) is a derivative of NAD+, which functions as a signaling molecule and enzyme cofactor. This compound is utilized in screening gatekeeper mutations of PARP1 (poly[ADP-ribose] polymerase 1) that are sensitive to analogs.

8-MA-NAD+ (sodium) (8-Methylamino-NAD+ (sodium)) is a derivative of the signaling molecule and enzyme cofactor NAD+. It is utilized for screening analog-sensitive gatekeeper mutations in poly (ADP-ribose) polymerase 1 (PARP1) and for synthesizing cyclic ADP-ribose (cADPR) derivatives.