nmda channel blocker

Lanicemine dihydrochloride (AZD-6765 dihydrochloride) is a low-capture NMDA channel blocker with antidepressant activity and can be used to study neurological diseases.

N20C hydrochloride (2-((3,3-diphenylpropyl)amino)acetamide hydrochloride) is a non-competitive NMDA receptor open-channel blocker.

Caged MK801 (cMK801) is a selective, noncompetitive, and irreversible blocker of the NMDA receptor open channel. The NVOC cage is compatible in neuropharmacology and does not alter the intrinsic activity of the molecule.

(Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker with a Ki of 0.56-2.1 μM for the NMDA receptor and IC50 values of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively. Lanicemine shows antidepressant effects [1].

(R)-Lanicemine ((R)-AZD6765), the less active R-enantiomer of Lanicemine, is a low-trapping NMDA channel blocker. It exhibits a binding affinity (Ki) of 0.56-2.1 μM for the NMDA receptor and shows inhibitory concentrations (IC50s) of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively. It has been associated with antidepressant effects [1].

CNS-5788 is a potential ischemia-selective N-methyl-D-aspartate (NMDA) receptor ion-channel blocker

Lanicemine is a low-trapping NMDA channel blocker. It also has a binding (Ki: 0.56-2.1 μM).