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nemiralisib

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  • Inhibitors & Agonists
    3
    TargetMol | Inhibitors_Agonists
Nemiralisib
GSK2269557
T154311254036-71-9In house
Nemiralisib(GSK-2269557 free base) is an orally available, potent and specific PI3Kδ inhibitor with a pKi of 9.9.Nemiralisib is used for the treatment of respiratory diseases including chronic obstructive pulmonary disease.
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6-8weeks
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Nemiralisib succinate
T708581364799-98-3
Nemiralisib succinate is a potent and selective PI3Kδ inhibitor.
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1-2 weeks
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3-Oxobetulin Acetate
T70856136587-07-0
3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin. It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50 = 0.12 µg ml), as well as human MCF-7 breast, SF-268 CNS, H460 lung, and KM20L2 colon cancer cells (GI50s = 8, 10.6, 5.2, and 12.7 µg ml, respectively), but not BxPC-3 pancreas or DU145 prostate cancer cells (GI50s = >10 µg ml for both). 3-Oxobetulin acetate inhibits replication of X4 tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblastoid cells (IC50 = 13.4 µM). It is also active against L. donovani amastigotes when used at a concentration of 50 µM.
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6-8 weeks
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