myristicin

Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with its inhibition of NO, cytokines,chemokines, and growth factors in dsRNA-stimulated macrophages via the calcium pathway. Myristicin can induce Apoptosis as characterised by alterations in the mitochondrial membrane potential, cytochrome c release, Caspase-3 activation, PARP-cleavage and DNA fragmentation.

Dihydromyristicin, a plant-derived flavonoid, possesses strong anti-inflammatory effects. It mitigates endotoxic inflammation by inhibiting the ROS-mediated activation of the PI3K Akt NF-κB signaling pathways [1].