murine metastatic melanoma model

Nicotinamide, a vitamin B3 derivative, is an inhibitor of SIRT1 (IC50=50-180 μM) and SIRT2 (IC50=2 μM). Nicotinamide can be used as a precursor of nicotinamide adenine dinucleotide or NAD+, which can be supplemented by dietary intake and can prevent or treat melanoglossia and pellagra.

Nicotinamide-15N,13C3 is a form of nicotinamide labeled with 13C and 15N. Nicotinamide, a vitamin B3, is crucial in cellular physiology by maintaining NAD+ redox balance and supplying NAD+ as a substrate for enzymes catalyzing non-redox reactions. Nicotinamide also acts as an SIRT1 inhibitor.

Nicotinamide Hydrochloride, a form of vitamin B3 (niacin), inhibits sirtuin 2 (SIRT2) activity in vitro with an EC50 of 2 μM, reducing melanoma cell number by up to 90% and increasing cellular NAD+, ATP, and ROS levels. It also inhibits tumor growth in vivo and improves survival in melanoma-bearing mice, making it useful for skin cancer research, including melanoma.

Nicotinamide (Standard) is the standard substance of Nicotinamide, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Nicotinamide, a vitamin B3 derivative, is an inhibitor of SIRT1 (IC50=50-180 μM) and SIRT2 (IC50=2 μM). Nicotinamide can be used as a precursor of nicotinamide adenine dinucleotide or NAD+, which can be supplemented by dietary intake and can prevent or treat melanoglossia and pellagra.

Nicotinamide ascorbate is a bioactive chemical.

Nicotinamide-13C6 is a 13C-labeled form of Nicotinamide. As a vitamin B3, Nicotinamide plays a crucial role in cellular physiology by supporting NAD+ redox homeostasis and serving as a substrate for a class of enzymes that catalyze non-redox reactions. It is also known as a SIRT1 inhibitor.

Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosylceramide, sphingomyelin, free fatty acids, and cholesterol in primary human keratinocytes. Nicotinamide (40 µM) induces apoptosis in SNU-398, SNU-739, and HepG2 hepatocellular carcinoma (HCC) cells, and it prevents the formation of neoplastic lesions in a diethylnitrosamine-induced mouse model of HCC. Unlike niacin, nicotinamide does not reduce plasma lipid levels or induce flushing.