mra

Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with transient elevations in serum aminotransferase levels, but has yet to be linked to cases of clinically apparent drug induced liver disease.

TAMRA-Azide-PEG-biotin is a PEG-based linker for PROTACs, joining two essential ligands. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

TAMRA-PEG3-Azide is a TAMRA red fluorescent dye linker with a maximum excitation/emission wavelength of 553/575 nm.

TAMRA-PEG4-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TAMRA-PEG4-Alkyne is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

(5,6)TAMRA-PEG3-Azide-PEG3-Desthiobiotin is a polyethylene glycol (PEG)-based PROTAC linker used for the synthesis of PROTACs.

Biotin-PEG4-Dde-TAMRA-PEG3-Azide is a seven-unit polyethylene glycol (PEG) linker used in the synthetic production of antibody-drug conjugates (ADCs) and is cleavable[1].

Dde Biotin-PEG4-TAMRA-PEG4 Alkyne, a PEG-based PROTAC linker, facilitates PROTAC synthesis[1].

TAMRA-PEG3-biotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

TAMRA-PEG4-methyltetrazine is a polyethylene glycol (PEG)-based linker employed for synthesizing proteolysis targeting chimeras (PROTACs)[1].

TAMRA-PEG4-tetrazine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

5-TAMRA can produce bright, pH insensitive orange fluorescence (Ex/ Em= 546 / 579nm), and has good photostability

TAMRA-Amyloid-β (1-42) peptide is a fluorescently labeled peptide. Amyloid-β (1-42) (Aβ42) is a neurotoxic 42-residue protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease. Aggregation of Aβ42 results in the formation of neurotoxic fibrils or globular oligomers. TAMRA-Amyloid-β (1-42) peptide is a labeled form of Aβ42 containing carboxytetramethyl rhodamine (TAMRA), which displays excitation/emission maxima of 543/572 nm, respectively.

MraY-IN-2 (compound 6) is a potent inhibitor of bacterial transposase MraY (IC50=4.5 μM), suitable for antibacterial research.

MraY-IN-3 (12a) is a potent inhibitor of bacterial translocase MraY with an IC50 of 140 μM and a concentration of 46 μg/ml.

MraY-IN-1 (compound 12a) is a potent inhibitor (IC50: 140 μM) of the bacterial translocase MraY. MraY-IN-1 has antibacterial activity against Escherichia coli K12 (MIC50: 7 μg/ml), Bacillus subtilis W23 (MIC50: 12 μg/ml) and Pseudomonas fluorescens Pf-5 (MIC50: 46 μg/ml). /MraY-IN-1 can be used for antimicrobial studies.

5-TAMRA cadaverine can used to modify carboxylic acid group in the presence of activators (e.g. EDC, or DCC) or activated esters (e.g. NHS esters) through a stable amide bond.

Pemrametostat succinate is an orally active, potent and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) that potently inhibits tumor growth in vitro and in vivo in animal models.

TAMRA alkyne, 6-isomer, a variant of the xanthene dye TAMRA, known for its orange emission, serves as a linker specifically designed for oligonucleotide labeling and amino acid sequencing. This isomer incorporates alkyne groups, enabling copper-catalyzed Click Chemistry reactions with azides [1].

MraY-IN-1 (compound 12a) is a potent inhibitor of MraY with an IC50 of 140 µM, exhibiting antimicrobial activity with MIC50 values of 7 µg/mL against Escherichia coli K12, 12 µg/mL for Bacillus subtilis W23, and 46 µg/mL for Pseudomonas fluorescens Pf-5, and is utilized in anti-bacterial research [1].

Bak BH3 (72-87), TAMRA-labeled, is a bioactive peptide.

Mram 8, a cyclotide isolated from Viola philippica of the Violaceae family [1], exhibits a characteristic cyclic peptide structure.

Omramotide is an immunological agent utilized for active immunization and possesses antineoplastic properties [1].

Emraclidine (CVL-231) is a novel, highly selective allosteric modulator of the muscarinic M4 receptor positive receptor for the study of neurological diseases.