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Results for "
monophosphoryl tri-acyl lipid a
" in TargetMol Product Catalog- Inhibitors & Agonists1
ADL 08-0011 HCl
T70267170098-43-8
ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan. It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM). It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg kg) reverses loperamide-induced delayed gastric emptying in a rat model of castor oil-induced diarrhea.
- $2,700
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QTY
ADL 08-0011
T20081156130-41-5
ADL-08-0011 is an metabolite of alvimopan.
- $2,220
Size
QTY
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