monophosphate synthetase

Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.

2'-Deoxyuridine 5'-monophosphate disodium (2'-dUMP⋅2Na) salt is utilized by the enzyme thymidylate synthetase (TS) for the de novo synthesis of dTMP and serves as the reference substrate in studies of dUMP analogues for potential chemotherapy applications.

LeuRS-IN-2 (Compound 9) acts as an inhibitor of Wolbachia Leucyl-tRNA synthetase (LeuRS) in the presence of adenosine monophosphate (AMP), exhibiting an EC50 value of 6 nM and effectively inhibiting the growth of pathogenic hosts. It forms an adenosine adduct to hinder protein synthesis and shows promise in studies aimed at developing new antimicrobial agents targeting microbial communities.