ml-161

Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thrombin-induced platelet activation.

ML161 analog 1 (compound 38) is a selective PAR1 allosteric inhibitor with an IC₅₀ of 1.68 μM. ML161 analog 1 is an analog of ML161.

V-161 is an orally active Na+-V-ATPase inhibitor with an IC50 of 144 nM. Under alkaline conditions, V-161 inhibits Enterococcus hirae and vancomycin-resistant Enterococcus faecium (VRE), with MIC values of 4 µg/mL for both. Additionally, V-161 can inhibit the colonization of VRE in the mouse small intestine.