mk1775

Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.

MK-1775 hemihydrate is a WEE1 inhibitor with potential antineoplastic sensitizing activity.

Quinapril-D5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril (T204362) is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril (T204362) prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations containing quinapril have been used in the treatment of hypertension, heart failure, and diabetic nephropathy.

Adavosertib (AZD1775; MK-1775) acid (Compound 9) is a derivative of AZD1775, useful in the synthesis of PROTAC.