metronidazole

Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.

Metronidazole Benzoate (Benzoyl metronidazole) is a derivative of Metronidazole and benzoic acid, which has antibacterial, anti-parasitic and anti-trichomonas functions and is often used to treat infections caused by anaerobic bacteria.

Metronidazole hydrochloride (SC 326421), an orally active nitroimidazole antibiotic, is effective for researching anaerobic infections. This compound is capable of crossing the blood-brain barrier and may cause inflammation and skeletal muscle contraction with long-term use [1] [2] [3] [4].

Metronidazole (acetic acid) is a metabolite derived from Metronidazole, exhibiting mutagenic activity in bacteria. As a nitroimidazole antibiotic, amebicide, and antiprotozoal agent, Metronidazole is specifically utilized against protozoa and anaerobic bacteria.

Metronidazole-d4 is a deuterium labeled compound for Metronidazole, which can be used for isotopic tracing.Metronidazole is a synthetic nitroimidazole derivative, an antibiotic and antiprotozoal agent with oral activity and blood-brain-barrier penetration for infections caused by anaerobic bacteria.

Metronidazole-d3 is a deuterated compound of Metronidazole.

Hydroxy Metronidazole-d4 is a deuterated compound of Hydroxy Metronidazole. Hydroxy Metronidazole has a CAS number of 4812-40-2. Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle.

Metronidazole-hydroxy-d2 is a deuterated compound of Metronidazole-hydroxy. Metronidazole-hydroxy has a CAS number of 4812-40-2.

Metronidazole KLH is an antigen-adjuvant conjugate of Metronidazole with keyhole limpet hemocyanin (KLH). Conjugating the antigen with a protein adjuvant can enhance the production of antigen-specific antibodies in vaccine models. The conjugate does not disrupt protein folding or alter main epitopes and can increase cross-presentation and the generation of antigen-specific T cells.

Metronidazole OVA is an antigen-adjuvant conjugate of Metronidazole with ovalbumin (OVA). Conjugating the antigen with a protein adjuvant can enhance the production of antigen-specific antibodies in vaccine models. The conjugate does not interfere with protein folding or disrupt primary epitopes and can improve cross-presentation and the generation of antigen-specific T cells.

Metronidazole BSA is an antigen-adjuvant conjugate composed of metronidazole and bovine serum albumin (BSA). This conjugate, in combination with a protein adjuvant, is able to enhance antibody production against a specific antigen in vaccine models. The conjugate does not interfere with protein folding or disrupt major epitopes and helps enhance cross-presentation and the generation of antigen-specific T cells.

Hydroxymetronidazole (Metronidazole-OH) is a nitroimidazole compound and metabolite of Metronidazole, commonly used in poultry research for bacterial and protozoal diseases, and in studies of swine dysentery and genital trichomoniasis in cattle.

Isometronidazole (RO-07-1502) is a chemical compound. The chemical compound is a derivative of the nitroimidazole family. Its molecular formula is C6H9N3O3. Isometronidazole can actually be used in the treatment of radiation therapy. The compound is known as a hypoxic cell sensitizer (radiosensitizer), increasing the efficacy of radiation treatment. Isometronidazole (RO-07-1502), a nitroimidazole derivative with the molecular formula C6H9N3O3, acts as a hypoxic cell sensitizer (radiosensitizer) in radiation therapy, enhancing the efficacy of the treatment.

Dehydroemetine is an effective antigenic insecticide, which is a synthetic analogue of Emetine dihydrochloride. It can be used to prevent and treat amoeba infections and diseases. It has the effect of treating leishmania infection with skin damage and resistance to metronidazole amoebiosis.

Tinidazole (CP12574)a is a 5-nitroimidazole derivative with the antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group, in turn, is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death.

trans-Cyclohexane-1,2-diol (trans-1,2-Cyclohexanediol) has a synergistic retardation effect on percutaneous absorption and penetration of metronidazole (MTZ).

Ridinilazole (SMT19969) is a novel narrow-spectrum nonabsorbable antibiotic. Ridinilazole showed potent inhibition of C. difficile (MIC90=0.125 mg L) and was markedly more active than either metronidazole (MIC90 = 8 mg L) or vancomycin (MIC90 = 2 mg L).

SC 28538 is a 5-nitroimidazolederivative which has been shown to be active against B. fragilis, C. perfringens, T. vaginalis, T. foetus, P.hominis and N. gonorrhoea in various in vitroscreening models. In comparative studies with284 strains of anaerobic bacteria SC 28538 wasfound to be as active as metronidazole or ornidazole.

N-(2-hydroxyethyl)-oxamic acid, a compound derived from the reduction of Metronidazole, can result from either chemical processes or through interaction with intestinal bacteria. Metronidazole itself is a nitroimidazole antibiotic with a broad range of efficacy against protozoans, as well as both Gram-negative and Gram-positive anaerobic bacteria.