methyltetrazine-acid

Methyltetrazine-acid is an alkyl chain-derived linker used for PROTAC synthesis [1].

Methyltetrazine-PEG8-acid is a polyethylene glycol (PEG) derivative commonly employed as a linker in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Methyltetrazine-PEG13-acid is a PEGylated linker derived from PEG that serves as a valuable component in the production of PROTACs, a class of compounds known for their targeted protein degradation properties[1].

Methyltetrazine-PEG25-acid, a PEG-derived PROTAC linker, is used for the synthesis of PROTACs[1].

Methyltetrazine-PEG4-acid, a PEG-based linker, is employed in the synthesis of PROTACs[1].

Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent featuring a tetrazine group, capable of undergoing inverse electron demand Diels-Alder (iEDDA) reactions with molecules containing TCO groups. This PEGylated derivative possesses a methyltetrazine moiety and two acidic groups. It forms stable covalent bonds with TCO-bearing compounds through a rapid and selective Diels-Alder cycloaddition, without the need for Cu catalysis or high temperatures. Additionally, its terminal carboxylic acids can react with primary amines in the presence of activators (such as EDC or HATU) to form stable amide bonds. The PEG linkage enhances the compounds water solubility. This reagent is for research use only.

Methyltetrazine-PEG12-acid is a polyethylene glycol-based click chemistry reagent featuring a tetrazine group. Click chemistry offers significant application potential for linking nucleic acids, lipids, proteins, and other molecules, thanks to its beneficial properties such as high yield, high specificity, and simplicity, making it valuable across numerous research areas.