methylene blue

Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.

Dimethyl methylene blue zinc chloride double salt (DMMB) is a cationic dye. It competitively binds with endotoxins at the active sites of PANI-Benz-Ag nanocomposites, releasing DMMB and enhancing fluorescence intensity. This compound serves as a fluorescent probe for the detection of bacterial endotoxins, such as those in E. Coli.

Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate is used as a bacteriologic stain and as an indicator. It inhibits soluble guanylyl cyclase and has been used to treat cyanide poisoning and to lower levels of methemoglobin. It also inhibits tau filament formation (IC50: 1.9μM).

Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.

Acetyl methylene blue can be utilized in the synthesis of mitochondrial biogenesis stimulators, which are applicable in treating ocular diseases associated with mitochondrial dysfunction in neuronal cells.

1,9-Dimethylmethylene blue is a fluorescent dye used for the detection of chondroitin sulfate.

Coelenteramine 400a (Coelenterazine 400a), a Coelenterazine derivative, serves as a substrate for Renilla luciferase (RLuc), facilitating the emission of blue light at 395 nm [1] [2]. This compound alters the bioluminescence color of RLuc by substituting the sulfur and oxygen heteroatoms in the methylene bridge. Coelenteramine 400a enhances signal resolution, proving useful in bioluminescence resonance energy transfer (BRET) research [3].

Azure B (Azure B chloride) is a cationic dye and the major metabolite of Methylene blue. Azure B is a selective, and reversible inhibitor of MAO-A (IC50s: 11 and 968 nM for recombinant human MAO-A and MAO-B).

Azure A (chloride), a phenothiazine dye, is produced through the oxidation of methylene blue and exhibits strong metachromatic properties. This compound is useful in studying stains and serves as a redox medium in electrochemical biosensing applications [1] [2].

Azure C, the product of sequential enzymatic oxidation of Methylene blue (MB) or Azure B (AB), serves as the substrate of horseradish peroxidase (HRP) [1] [2].

Azure A chloride (Standard) is the standard of Azure A chloride (T85788), suitable for research related to quantitative analysis, quality control, and biochemical experiments. Azure A (chloride) is a phenothiazine dye formed by oxidation of methylene blue, exhibiting strong metachromasia. Azure A (chloride) is used in studies of stains and redox mediators for electrochemical biosensing.

Azure B (Standard) is the standard of Azure B (T18918), suitable for research related to quantitative analysis, quality control, and biochemical experiments. Azure B is a phenothiazine cationic dye and the key active metabolite of methylene blue in vivo. It has two main application directions: as a core component of Romanowsky-Giemsa stain, forming charge-transfer complexes with Eosin Y on target substrates, producing a purple color in stained biological samples (the "Romanowsky-Giemsa effect"), which is a key mechanism for identifying cells and pathogens in fields such as hematopathology and microbiology; and as a potent, reversible, and selective inhibitor of monoamine oxidase A (MAO-A) (IC50 = 11 nM for human recombinant MAO-A, 968 nM for MAO-B).