methyl-lysine

UNC926 (UNC-926) inhibits L3MBTL1 (IC50: 3.9 μM). UNC926 also exhibits a low micromolar affinity for L3MBTL3. UNC926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively and dose-dependently inhibits the L3MBTL13xMBT-H4K20me1 interaction. UNC926 has not an effect on the binding of 53BP1 to H4K20me1.

UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.

UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold higher versus other members of the human MBT family.

N-Methyl-lysine-CoA (N-Methyl-lysine-coenzyme A) is a derivative of coenzyme A.

N-Dimethyl-lysine-CoA (N-Dimethyl-lysine-coenzyme A) is a derivative of coenzyme A.

Nε,Nε,Nε-Trimethyllysine chloride (Lys(Me)3-OH Chloride) is a methylated derivative of lysine, found in histone proteins and serves as a coenzyme in fatty acid oxidation. It is a precursor for carnitine, generated by S-adenosyl-L-methionine on lysine residues. Upon proteolysis, it is converted to 3-hydroxy-6-N-trimethyllysine by mitochondrial 6-N-trimethyllysine dioxygenase, initiating carnitine biosynthesis.

Nε,Nε,Nε-Trimethyllysine-13C3chloride is the 13C-labeled version of Nε,Nε,Nε-Trimethyllysine chloride. Nε,Nε,Nε-Trimethyllysine chloride serves as a precursor for the gut microbiota-dependent formation of N,N,N-trimethyl-5-aminovaleric acid (TMAVA).

UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.

Gintemetostat (KTX-1001) is a potent and selective small molecule inhibitor of nuclear receptor-binding SET domain protein 2 (NSD2), exhibiting IC50 values ranging from 0.001 μM to 0.01 μM, and it belongs to the chemical class of piperidinyl-methyl-purineamine derivatives, with primary research applications in oncology for the treatment of NSD2-dysregulated cancers.

L-Lysine, mono(2-(((3-phenyl-1,2,4-oxadiazol-5-yl)methyl)thio)propanoate) can be used in related research in the field of life sciences. Its product number is T32817 and CAS number is 61560-15-4.

D-Lysine lactam is a chiral compound suitable for biochemical experiments and drug synthesis research.

Aminoadipic acid (DL-2-Aminoadipic acid) (2-aminoadipate) is a metabolite in the principal biochemical pathway of lysine. It is an intermediate in the metabolism (i.e. breakdown or degradation) of lysine and saccharopine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor N-methyl-D-aspartate (NMDA). Aminoadipic acid has also been shown to inhibit the production of kynurenic acid, a broad spectrum excitatory amino acid receptor antagonist, in brain tissue slices.

UNC9512 is a potent antagonist of the methyl-lysine reader protein 53BP1, which can be utilized to investigate the function of 53BP1 in DNA repair, gene editing, and tumorigenesis [1].

UNC3474, a small molecule ligand, selectively interacts with the aromatic methyl-lysine binding cage of the tumor protein 53BP1 Tudor domain (TT), exhibiting a dissociation constant (Kd) of 1.0±0.3 μM. It impedes 53BP1's recruitment to DNA double-strand breaks (DSBs), maintaining the protein's autoinhibited state within cells [1].

Nε-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end-product (AGE), resulting from the chemical modification of proteins by methylglyoxal. Exposure to CEL reduces glutamate uptake and S100B secretion in the hippocampus, making it useful for studying ageing, metabolism, and diabetes.

Aminoadipic acid (Standard) is a reference standard for research and analysis in studies involving Aminoadipic acid. Aminoadipic acid (DL-2-Aminoadipic acid) (2-aminoadipate) is a metabolite in the principal biochemical pathway of lysine. It is an intermediate in the metabolism (i.e. breakdown or degradation) of lysine and saccharopine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor N-methyl-D-aspartate (NMDA). Aminoadipic acid has also been shown to inhibit the production of kynurenic acid, a broad spectrum excitatory amino acid receptor antagonist, in brain tissue slices.

2'-O-Methyl-5-methyl uridine is a thymidine nucleoside analog and a component of lysine transfer RNA in rabbit liver, suitable for biochemical experiments and drug synthesis research.