mehp

Phthalic acid mono-2-ethylhexyl ester (Phthalic Acid Monooctyl Ester) is a major bioactive metabolite of diethylhexyl phthalate (DEHP), which inhibits the 17,20 lyase activity of CYP17. The Cyp17a1 gene is specifically targeted by MEHP, explaining the MEHP-induced suppression of steroidogenesis observed.

Mono (2-ethyl-5-oxohexyl) phthalate (5-oxo-MEHP) is an oxidative metabolite of Di (2-ethylhexyl) phthalate (DEHP). Mono (2-ethyl-5-oxohexyl) phthalate may offer protection against sperm DNA damage. Di (2-ethylhexyl) phthalate is primarily used as a plasticizer in rigid polyvinyl chloride (PVC) to enhance flexibility, temperature resistance, optical clarity, strength, and kink resistance.

Mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) is a metabolite of mono(2-ethylhexyl) phthalate (MEHP) and a secondary metabolite of di(2-ethylhexyl) phthalate (DEHP). DEHP is a plasticiser used in polyvinyl chloride (PVC).