median — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T19940	Sulfoxaflor	GF 2372,GF 2032,XDE 208	AChR
	Sulfoxaflor (GF 2032), an agonist of nAChR1 and nAChR2 subtypes, is a systemic insecticide that acts on the central nervous system of insects. Sulfoxaflor is used for the control of sap-feeding insects such as Nilaparvat...		AChR
T2S2169	Naringenin trimethyl ether	5,7,4'-Trimethoxyflavanone	Others
	1. Naringenin trimethyl ether (5,7,4'-Trimethoxyflavanone) shows significant molluscicidal activity with a median lethal concentration (LC(5)) of 3.9 μg/mL.		Others
TN1343	8-Geranyloxypsoralen		Anti-infection , P450 , BACE
	8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arterial tissues. 8-Geranyloxypsoralen possesses nematicidal act...		Anti-infection , P450 , BACE
TQ0291	Firategrast	SB 683699	Integrin
	Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist.Firategrast reduces the transport of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity...		Integrin
T71182	N 0745
	N 0745 inhibits 2-[125I]-iodomelatonin binding to median eminence/pars tuberalis membranes with an affinity similar to that of melatonin.
T15472	Hepsulfam	NCI 329680,ZINC01574758	Others
	Hepsulfam is an anticancer agent. It also displays excellent antileukemic activity (a median IC50: 0.91 μg/mL in a panel of different tumors).		Others
T71774	Territrem B
	Territrem B is a mycotoxin that irreversibly inhibits acetylcholinesterase (AChE). It is toxic to mice, inducing tremors with a median tremulous dose of 0.21 mg/kg.
T69821	AMP423
	AMP423 is a naphthyl derivative of 2-cyanoaziridine-1-carboxamide with structural similarity to the pro-oxidant anti-tumor agent imexon. AMP423 was active in SCID mice bearing 8226/S myeloma and SU-DHL-6 B-cell lymphoma ...
T74614	PROTAC Hemagglutinin Degrader-1
	PROTAC Hemagglutinin Degrader-1 (Compound V3) is a potent degrader of influenza hemaglutinin (HA), demonstrating a median degradation concentration of 1.44 μM and exhibiting broad-spectrum anti-influenza virus activity [...
T28494	R-82913	NSC 637653, 9-Cl-Tibo,R 82913,R82913. 9-Cmbib
	R-82913 is a RNA-directed DNA polymerase inhibitor. R 82913 reduce 5-HT2 receptor-mediated DOI-head-shakes in mice. R82913 inhibited the replication of thirteen different strains of HIV-1 in CEM cells with a median IC50 ...
T37435	PACAP-related Peptide (rat) (trifluoroacetate salt)		PACAP
	PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adeny...		PACAP
T80185	Huwentoxin I	HWTX-I	Calcium Channel
	Huwentoxin I (HWTX-I) is a peptide toxin that targets and inhibits both voltage-gated sodium channels and N-type calcium channels. It effectively inhibits sodium channels in the rat hippocampus and cockroach dorsal unpai...		Calcium Channel
T79067	PROTAC BTK Degrader-3		PROTACs
	PROTAC BTK Degrader-3 is a potent degrader of Bruton's tyrosine kinase (BTK), exhibiting a DC50 (median degradation concentration) of 10.9 nM in Mino cells. This compound shows promise for research into B-cell malignanci...		PROTACs
TN4084	Fumitremorgin B		Antifection
	Fumitremorgen B is a mycotoxin, it exhibits a certain degree of genotoxicity, it can cause DNA damage in human lymphocytes; it shows an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the M ph...		Antifection
T38193	β-Endorphin (1-27) (human) (trifluoroacetate salt)
	β-Endorphin (1-27) is an endogenous peptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors). It binds to rat and mouse brain membrane p...