mcl 1/bcl 2 in 3

MCL-1/BCL-2-IN-3 is a selective and potent dual inhibitor of Mcl-1 and Bcl-2, with IC50 values of 5.95 and 4.78 μM, respectively.

Bcl-2/Mcl-1-IN-3 is a Bcl-2/Mcl-1 inhibitor, targeting Mcl-1 (Ki: 0.14 μM) and Bcl-2 (Ki: 0.23 μM), suitable for cancer research.

Mcl-1-IN-20 (Compound 26d) is an Mcl-1 inhibitor displaying Ki values of 0.59 μM for Mcl-1, 6.6 μM for Bcl-xL, and 3.6 μM for Bcl-2. It exhibits significant antiproliferative activity against pancreatic cancer cells and induces apoptosis in BxPC-3 cells. Mcl-1-IN-20 is applicable in pancreatic cancer research.

Mcl-1-IN-16 is an effective macrolide inhibitor of myeloid cell leukemia 1 (Mcl-1) with a Ki of less than 0.08 nM. It demonstrates over 50,000-fold selectivity for Mcl-1 compared to other anti-apoptotic Bcl-2 family members, Bcl-2 and Bcl-xL. Mcl-1-IN-16 activates caspase-3/7, thereby inducing apoptosis. In tumor xenograft mouse models derived from lung cancer, it achieves tumor regression. Mcl-1-IN-16 is useful for research on solid tumors, including non-small cell lung cancer (NSCLC).