mal peg1 boc

Mal-PEG1-Boc is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Boc-HyNic-PEG1-mal is a PROTAC linker that belongs to the PEG class and is utilized in the synthesis of PROTAC molecules.

N-Boc-N'-(PEG1-t-butyl ester)-L-Lysine-amido-Mal is a lysine amino acid derivative with a maleimide group at the C-terminus. The α-amino group is protected by a Boc group, and the ε-amino group is capped with an amide-PEG1-t-butyl ester. The maleimide group is a thiol-reactive covalent moiety for attaching to cysteine residues, while the Boc and t-butyl ester groups can be deprotected for subsequent reactions.