locomotion

Tocofersolan (TPGS) is a polyethylene glycol derivative of α-tocopherol and synthetic water-soluble version of Tocopherol. Tocofersolan is an oral treatment of vitamin E deficiency due to digestive malabsorption in pediatric patients with congenital chronic cholestasis or hereditary chronic cholestasis.

SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.IC50 value: 9.0(pKi) [1]Target: 5-HT2C antagonistin vitro: SB 242084 had over 100-fold selectivity over a range of other 5-HT, dopamine and adrenergic receptors. In studies of 5-HT-stimulated phosphatidylinositol hydrolysis using SH-SY5Y cells stably expressing the cloned human 5-HT2C receptor, SB 242084 acted as an antagonist with a pKb of 9.3, which closely resembled its corresponding receptor binding affinity [1].in vivo: SB 242084 potently inhibited m-chlorophenylpiperazine (mCPP, 7 mgkg i.p. 20 min pre-test)-induced hypolocomotion in rats, a model of in vivo central 5-HT2C receptor function, with an ID50 of 0.11 mg kg i.p., and 2.0 mg kg p.o. SB 242084 (0.1-1 mg kg i.p.) exhibited an anxiolytic-like profile in the rat social interaction test, increasing time spent in social interaction, but having no effect on locomotion. SB 242084 (0.1-1 mg kg i.p.) also markedly increased punished responding in a rat Geller-Seifter conflict test of anxiety, but had no consistent effect on unpunished responding [1].

RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole) is a selective agonist of 5-HT1A and 5-HT1B receptors.

O-2050 is a high-affinity cannabinoid CB1 receptor antagonist with a Ki of 2.5 nM and inhibits the cannabinoid CB2 receptor with a Ki of 0.2 nM. O-2050 decreased food intake and stimulated locomotion in mice [1].

FAAH MAGL-IN-2, a potent and reversible inhibitor of FAAH and MAGL, demonstrates oral activity and the ability to cross the blood-brain barrier. It exhibits IC50 values of 11 nM for FAAH and 36 nM for MAGL (Ki values of 28 nM and 60 nM, respectively). This compound shows promise for neuropathic pain research, without impairing locomotion [1].

RU 24969 succinate, a 5-HT receptor agonist, exhibits K i values of 0.38 nM for 5-HT 1B and 2.5 nM for 5-HT 1A, indicating its affinity towards these receptors. It reduces fluid consumption and enhances forward locomotion. This compound is utilized in neurological disease research.

5-MeO-MET (5-Methoxy-N-methyl-N-ethyltryptamine) is a compound belonging to the 5-methoxytryptamine class. It acts as an agonist for 5-HT1A and 5-HT2A receptors. In mice, 5-MeO-MET inhibits locomotion and has sedative effects.

Neuropeptide S (Mouse) acetate is a bioactive peptide. Neuropeptide S (Mouse) acetate, as a neurotransmitter neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and drug addiction[1].

SKF38393 hydrobromide is the salt form of SKF38393.SKF38393 is a dopamine D1 receptor agonist that increases the expression of Shati Nat8L mRNA in the NAc of mice; increases the frequency of 5-hydroxytryptamine and n -methyl- D -aspartate-induced locomotion-associated ruptures in astrocytes; can mimic the dopamine-induced inhibition of colonic motility in mice; can promote locust swarming

Orphan neuropeptide,stimulates locomotion in mice