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loc-609365

" in TargetMol Product Catalog
  • Recombinant Protein
    1
    TargetMol | Recombinant_Protein
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CD46 Protein, Canine, Recombinant (His)
TRA2.10, TLX, MIC10, Membrane cofactor, MCP, LOC609365, CD46, AHUS2
TMPK-00570
CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated 'self-attack'. CD46 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 34.11 kDa and the accession number is A0A8C0YZN5.
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7-10 days
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SPR-compatible buffer
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CD46 Protein, Cynomolgus, Recombinant (His)
TRA2.10, TLX, MIC10, MCP, CD46, AHUS2
TMPK-00532
CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition on host tissue is underpinned by the fact that deficiency of CD46 is a predisposing factor for numerous disease conditions arising from complement-mediated 'self-attack'. CD46 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 34.05 kDa and the accession number is A0A2K5WCS2.
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7-10 days
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CAPG Protein, Human, Recombinant
MCP, HEL-S-66, capping protein (actin filament), gelsolin-like, AFCP
TMPY-03863
CAPG, also known as actin Regulatory Protein CAPG, is a a member of the gelsolin/villin family. Members of this family are actin-regulatory proteins. CAPG reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, CAPG contributes to the control of actin-based motility in non-muscle cells. CAPG may also play an important role in macrophage function.
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7-10 days
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CD46 Protein, Human, Recombinant (His)
TRA2.10, TLX, MIC10, MCP, CD46 molecule, complement regulatory protein, AHUS2
TMPY-02023
CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. Human CD46 shares 5% amino acid sequence identity with mouse and rat CD46. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome (aHUS), a disease characterized by uncontrolled complement activation. CD46 is implicated in the development and/or progression of selected cancer types.
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7-10 days
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